Evidence for a critical T cell - B cell interaction in tolerance induced by anti-CD45RB

Autor:	Jing Wang, Xiaolun Huang, Major K. Lee, Ergun Velidedeoglu, Muhammad M. Mohiuddin, Yong Suk Bae, James F. Markmann, Moh Moh Lian, Shaoping Deng, Paige Porret
Rok vydání:	2005
Předmět:	business.industry T cell CCL19 C-C chemokine receptor type 7 Stimulation CXCR4 Cell biology medicine.anatomical_structure Immunology T cell migration Medicine Surgery business Lymph node B cell
Zdroj:	Journal of the American College of Surgeons. 201:S92
ISSN:	1072-7515
DOI:	10.1016/j.jamcollsurg.2005.06.217
Popis:	RESULTS: Splenic T cell migration to CCL19 or CXCL12 is enhanced by, but does not require, S1P receptor stimulation. In contrast, lymph node T cell migration to CXCL12 but not CCL19 requires both chemokine and S1P receptor stimulation. The requirement for CXCR4 and S1PR stimulation of lymph node T cells is particularly important for mechanisms involving transendothelial migration of T cells. The results also demonstrate that: 1) splenic versus lymph node T cells use different molecular migration mechanisms; 2) CCR7 and CXCR4 stimulation engage different molecular migration mechanisms; and 3) S1P and FTY720 have distinct S1PR agonist and antagonist properties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a97bfc7bf4d14a77367c26f23d2bf6c3 https://doi.org/10.1016/j.jamcollsurg.2005.06.217 Zobrazit plný text záznamu