Determinants of bone mineral density in prematurely born children aged 6-7 years

Autor: E Länsimies, K Launiala, Sangita Kurl, Kirsti Heinonen
Rok vydání: 2007
Předmět:
Zdroj: Acta Paediatrica. 87:650-653
ISSN: 0803-5253
DOI: 10.1111/j.1651-2227.1998.tb01525.x
Popis: The aim of this study was to assess the long-term effects of prematurity and growth during the first year on bone mineralization in prematurely born children. The study group consisted of 38 prematurely born Finnish children ( 17M, 21F) examined at the age of 6-7 y. After birth, all children were fed with banked human milk until discharge from hospital. Thereafter, 27 children were partially breastfed until the age of 5-7 months. Infants with gestational age (GA) ≤ 33 weeks (n = 25) received calcium 45-50mg/100 kcal, phosphorus 40-45 mg/100 kcal, vitamin A 1000 IU/d, vitamin C 2 mg/d and vitamin D 400 IU/d until 2.5kg. Infants born > 33 weeks received only vitamin D 400 IU/d, Bone mineral density (BMD) and bone mineral content (BMC) were measured by dual energy X-ray absorptiometry (DXA) of the lumbar spine (L2-L4) at 6-7 y of age. At examination. all children had normal height and weight. BMD values were within the confidence interval of the Finnish reference values. In regression analysis bone area, present weight, GA and weight at I y were the most significant factors explaining 77.1% of the variance of BMC. After adjusting for other independent variables the prematurely born children who were thinner at I y of age subsequently had higher BMC values when examined at the age of 6-7 y. This study shows that growth patterns during the first year of life have long-term effects on bone mineralization.
Databáze: OpenAIRE
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