In vivo and in vitro release of ivermectin from poly(ortho ester) matrices. I. Crosslinked matrix prepared from ketene acetal end-capped prepolymer

Autor:	R.L. Seward, Joseph A. Fix, Chung Shih
Rok vydání:	1993
Předmět:	Active ingredient chemistry.chemical_compound Pharmacokinetics Chemistry In vivo Polymer chemistry Acetal Pharmaceutical Science Liberation Ketene Orthoester Prepolymer
Zdroj:	Journal of Controlled Release. 25:155-162
ISSN:	0168-3659
DOI:	10.1016/0168-3659(93)90104-d
Popis:	Release of ivermectin from a crosslinked poly(ortho ester) matrix was studied both in vitro and in vivo in rats and dogs. A total of 32.8% of the loaded drug was covalently bonded to the polymer matrix. The release rate of the drug in vitro was initially slow but accelerated in the later stages of the studies. The rat plasma concentration of the drug was maintained fairly constant over a period of 6 months with a slight increase thereafter. Implant retrieval studies in dogs showed that the drug release may be controlled by matrix erosion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a97a60935234f72edd48781d7b25c2ac https://doi.org/10.1016/0168-3659(93)90104-d Zobrazit plný text záznamu