Unlocking Tissue Regenerative Potential by Epigenetic Reprogramming
| Autor: | Pradeep Reddy, Juan Carlos Izpisua Belmonte, Sebastian Memczak |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
genetic structures Regeneration (biology) Glaucoma Cell Biology Biology medicine.disease Retinal ganglion eye diseases 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure SOX2 KLF4 embryonic structures Genetics medicine Molecular Medicine sense organs biological phenomena cell phenomena and immunity Axon Reprogramming Neuroscience 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Cell Stem Cell. 28:5-7 |
| ISSN: | 1934-5909 |
| Popis: | Summary The regeneration potential of axons projecting from retinal ganglion cells (RGCs) is lost shortly after birth. In Nature, Lu et al. (2020) demonstrate that epigenetic reprogramming of RGCs by overexpression of Oct4, Sox2, and Klf4 leads to axon regeneration and restoration of vision in a glaucoma model and aged mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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