Tracheal aspirate transcriptomic and miRNA signatures of extreme premature birth with bronchopulmonary dysplasia
| Autor: | Neal J. Thomas, Yuka Imamura-Kawasawa, Ann Donnelly, Roopa Siddaiah, Nathalie Fuentes, Debra Spear, Patricia Silveyra, Deborah T. Montes, Christiana N. Oji-Mmuo, Judie A. Howrylak, Melody A Pham |
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| Rok vydání: | 2020 |
| Předmět: |
Mechanical ventilation
education.field_of_study business.industry medicine.medical_treatment Population Obstetrics and Gynecology medicine.disease Bioinformatics Pathogenesis Transcriptome 03 medical and health sciences 0302 clinical medicine Bronchopulmonary dysplasia Premature birth 030225 pediatrics Intensive care mental disorders Pediatrics Perinatology and Child Health medicine Biomarker (medicine) 030212 general & internal medicine business education |
| Zdroj: | Journal of Perinatology. 41:551-561 |
| ISSN: | 1476-5543 0743-8346 |
| Popis: | Objective Extreme preterm infants are a growing population in neonatal intensive care units who carry a high mortality and morbidity. Multiple factors play a role in preterm birth, resulting in major impact on organogenesis leading to complications including bronchopulmonary dysplasia (BPD). The goal of this study was to identify biomarker signatures associated with prematurity and BPD. Study design We analyzed miRNA and mRNA profiles in tracheal aspirates (TAs) from 55 infants receiving invasive mechanical ventilation. Twenty-eight infants were extremely preterm and diagnosed with BPD, and 27 were term babies receiving invasive mechanical ventilation for elective procedures. Result We found 22 miRNAs and 33 genes differentially expressed (FDR Conclusions Specific mRNA-miRNA signatures in TAs may serve as biomarkers for BPD pathogenesis, a consequence of extreme prematurity. |
| Databáze: | OpenAIRE |
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