Interconversion between S- and N-bound L-methionine adducts of Pt(dien)2+ (dien = diethylenetriamine) via dien ring-opened intermediates

Autor:	Erle Zang, Peter J. Sadler, Yu Chen, Zijian Guo, Piedad del Socorro Murdoch
Rok vydání:	1998
Předmět:	chemistry.chemical_compound Chemistry Stereochemistry Diethylenetriamine Diastereomer General Chemistry Nuclear magnetic resonance spectroscopy Spectroscopy Ring (chemistry) Two-dimensional nuclear magnetic resonance spectroscopy High-performance liquid chromatography Adduct
Zdroj:	Journal of the Chemical Society, Dalton Transactions. :1503-1508
ISSN:	1364-5447 0300-9246
DOI:	10.1039/a709282b
Popis:	The reaction between [Pt(15N-dien)Cl]+ 1 and L-methionine (L-MetH) has been studied using [1H,15N] 2D NMR spectroscopy and HPLC, together with 15N-labelled amine ligands. The complex [Pt(dien)(L-MetH-S)]2+ 2 was dominant at neutral pH and converted partially and reversibly into [Pt(dien)(L-Met-N)]+ 3 at pH >8. When the pH was lowered from 8 to 3, the dien ring-opened intermediate [Pt(dienH-N,N′)(L-Met-S,N)]2+ 4 was formed which converted slowly into complex 2. Complex 4 was separated by HPLC and characterized by NMR spectroscopy as a mixture of four diastereomers (due to chiral centres at S and NH) present in a 2∶2∶1∶1 molar ratio. This isolated intermediate had a surprisingly long lifetime (days) in 0.55 M NH4H2PO4 (pH 4.0).
Databáze:	OpenAIRE
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