A comparison of clinical, magnetic resonance imaging and pathological findings in dogs with gliomatosis cerebri, focusing on cases with minimal magnetic resonance imaging changes‡
| Autor: | R. Longshore, K. Kopf, G. N. Burcham, R. T. Bentley, Margaret A. Miller, Hock Gan Heng, Starr Cameron, Jonathan M. Levine, S. Carrera-Justiz |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Pathology 040301 veterinary sciences Gliomatosis cerebri Physical examination 0403 veterinary science Lesion 03 medical and health sciences 0302 clinical medicine Glioma medicine Pathological General Veterinary medicine.diagnostic_test Glial fibrillary acidic protein biology business.industry Magnetic resonance imaging 04 agricultural and veterinary sciences medicine.disease 030220 oncology & carcinogenesis biology.protein Radiology medicine.symptom Differential diagnosis business |
| Zdroj: | Veterinary and Comparative Oncology. 14:318-330 |
| ISSN: | 1476-5810 |
| DOI: | 10.1111/vco.12106 |
| Popis: | The primary study objective was to determine whether clinical examination and magnetic resonance imaging (MRI) can underestimate canine gliomatosis cerebri (GC); we also investigated immunohistochemical features. Seven dogs with GC were studied; four recruited specifically because of minimal MRI changes. Neuroanatomic localization and the distribution of MRI, gross and sub-gross lesions were compared with the actual histological distribution of neoplastic cells. In six cases, clinical examination predicted focal disease and MRI demonstrated a single lesion or appeared normal. Neoplastic cells infiltrated many regions deemed normal by clinical examination and MRI, and were Olig2-positive and glial fibrillary acid protein-negative. Four dogs had concurrent gliomas. GC is a differential diagnosis for dogs with focal neurological deficits and a normal MRI or a focal MRI lesion. Canine GC is probably mainly oligodendrocytic. Type II GC, a solid glioma accompanying diffuse central nervous system neoplastic infiltration, occurs in dogs as in people. |
| Databáze: | OpenAIRE |
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