Structure of the lysine specific protease Kgp from P orphyromonas gingivalis , a target for improved oral health

Autor:	Belinda J. Michell, Christine A. Seers, Susanne C. Feil, Keith J. Cross, Michael W. Parker, Michael A. Gorman, Eric C. Reynolds, N. Laila Huq
Rok vydání:	2014
Předmět:	Protease biology Chemistry medicine.medical_treatment Virulence biology.organism_classification Biochemistry Cysteine protease Virulence factor Microbiology Bacterial adhesin Gingipain stomatognathic diseases medicine Molecular Biology Porphyromonas gingivalis Pathogen
Zdroj:	Protein Science. 24:162-166
ISSN:	0961-8368
DOI:	10.1002/pro.2589
Popis:	The oral pathogen Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Gingipains, the principle virulence factors of P. gingivalis are multidomain, cell-surface proteins containing a cysteine protease domain. The lysine specific gingipain, Kgp, is a critical virulence factor of P. gingivalis. We have determined the X-ray crystal structure of the lysine-specific protease domain of Kgp to 1.6 A resolution. The structure provides insights into the mechanism of substrate specificity and catalysis.
Databáze:	OpenAIRE
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