ORIGINAL ARTICLE: Multiple Cytokine Profile in Plasma and Amniotic Fluid in a Mouse Model of Pre-Term Labor
| Autor: | Yael Rosenberg-Hasson, James Schilling, David L. Hirschberg, Yasser Y. El-Sayed, Qing Yang, Ashima Madan, Nihar R. Nayak |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Chemokine Amniotic fluid Preterm labor Lipopolysaccharide biology business.industry medicine.medical_treatment Cytokine profile Immunology Obstetrics and Gynecology Stimulation Inflammation chemistry.chemical_compound Cytokine Endocrinology Reproductive Medicine chemistry Internal medicine medicine biology.protein Immunology and Allergy medicine.symptom business |
| Zdroj: | American Journal of Reproductive Immunology. 62:339-347 |
| ISSN: | 1046-7408 |
| Popis: | Problem The rate of pre-term birth in the United States continues to rise despite several interventions. Induction of pro-inflammatory cytokines and chemokines has been implicated in the activation of the cascade of events resulting in pre-term labor. To date, no comprehensive panel of the cytokine profile in PTL has been published. Method of study To address cytokine profiles in pre-term labor, levels of 19 plasma and amniotic fluid cytokines were measured using a multiplex immunoassay in an inflammation-induced murine model of pre-term labor. Results Pro-inflammatory mediators, RANTES, KC, IL-6, and IL-12p40 were increased by 3 hr and remained high at 15 hr. Concentrations of KC, IL-6, IL-1β, and MIP-1α were increased in the amniotic fluid at 15 hr. Plasma levels of anti-inflammatory mediators IL-10 and IL-13 at 15 hr were unchanged and decreased respectively. Conclusion These results suggest that stimulation of several pro-inflammatory cytokines occurs very early in the cascade of events and remains increased, whereas anti-inflammatory cytokines are either unchanged or decreased until the onset of delivery in an inflammation-induced mouse model of pre-term labor. |
| Databáze: | OpenAIRE |
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