| Autor: |
Daniela Münzel, Florian Fischer, Tobias J. Schröter, Fabio De Marco, Andre Yaroshenko, Christian Braun, Maximilian F. Reiser, Jürgen Mohr, Thomas Pralow, Martin Renz, Sigrid Auweter, Nataly Wieberneit, Roland Proksa, Hanns-Ingo Maack, Kai Scherer, Julia Herzen, Karsten Rindt, Thomas Köhler, Peter B. Noël, Alexander A. Fingerle, Katharina Hellbach, Hendrik van der Heijden, Franz Pfeiffer, Ernst J. Rummeny, Konstantin Willer, Lukas B. Gromann, Bernhard Gleich, Klaus Achterhold, Bernhard Renger |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Medical Imaging 2017: Physics of Medical Imaging. |
| Popis: |
Purpose: To evaluate the performance of an experimental X-ray dark-field radiography system for chest imaging in humans and to compare with conventional diagnostic imaging. Materials and Methods: The study was institutional review board (IRB) approved. A single human cadaver (52 years, female, height: 173 cm, weight: 84 kg, chest circumference: 97 cm) was imaged within 24 hours post mortem on the experimental x-ray dark-field system. In addition, the cadaver was imaged on a clinical CT system to obtain a reference scan. The grating-based dark-field radiography setup was equipped with a set of three gratings to enable grating-based dark-field contrast x-ray imaging. The prototype operates at an acceleration voltage of up to 70 kVp and with a field-of-view large enough for clinical chest x-ray (>35 x 35 cm2). Results: It was feasible to extract x-ray dark-field signal of the whole human thorax, clearly demonstrating that human x-ray dark-field chest radiography is feasible. Lung tissue produced strong scattering, reflected in a pronounced x-ray dark-field signal. The ribcage and the backbone are less prominent than the lung but are also distinguishable. Finally, the soft tissue is not present in the dark-field radiography. The regions of the lungs affected by edema, as verified by CT, showed less dark-field signal compared to healthy lung tissue. Conclusion: Our results reveal the current status of translating dark-field imaging from a micro (small animal) scale to a macro (patient) scale. The performance of the experimental x-ray dark-field radiography setup offers, for the first time, obtaining multi-contrast chest x-ray images (attenuation and dark-field signal) from a human cadaver. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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