ChemInform Abstract: Synthesis and Biological Evaluation of N-(7-Indolyl)-3-pyridinesulfonamide Derivatives as Potent Antitumor Agents

Autor:	Kentaro Yoshimatsu, Takashi Owa, Nozomu Koyanagi, Takeshi Nagasu, Tadashi Okabe, Naoko Hata Sugi, Tatsuo Okauchi, Yoichi Ozawa, Kyosuke Kitoh, Hiroshi Yoshino
Rok vydání:	2010
Předmět:	Antitumor activity Chemistry Sulfonamide (medicine) medicine Phases of clinical research Moiety General Medicine Pharmacology Toxicity profile Human colon Biological evaluation medicine.drug
Zdroj:	ChemInform. 33
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200249130
Popis:	We herein report the synthesis and antitumor activity of E7070 analogues containing a 3-pyridinesulfonamide moiety. E7070 was selected from our sulfonamide-based compound collections, currently undergoing Phase II clinical trials because of its tolerable toxicity profile and some antitumor responses in the Phase I setting. Of the analogues examined, ER-35745, a 6-amino-3-pyridinesulfonamide derivative, demonstrated significant oral efficacy against the HCT116 human colon carcinoma xenograft in nude mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a91dac1b672c162fa3b9c266f5bb18da https://doi.org/10.1002/chin.200249130 Zobrazit plný text záznamu Plný text