Single particle inductively coupled plasma mass spectrometry as screening tool for detection of particles
| Autor: | Eduardo Bolea, Francisco Laborda, Ana C. Gimenez-Ingalaturre, Juan R. Castillo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
010302 applied physics
Materials science Particle number Sample (material) 010401 analytical chemistry Analytical chemistry chemistry.chemical_element Critical value 01 natural sciences Atomic and Molecular Physics and Optics Standard deviation 0104 chemical sciences Analytical Chemistry chemistry Aluminium 0103 physical sciences Particle Limit (mathematics) Instrumentation Inductively coupled plasma mass spectrometry Spectroscopy |
| Zdroj: | Spectrochimica Acta Part B: Atomic Spectroscopy. 159:105654 |
| ISSN: | 0584-8547 |
| DOI: | 10.1016/j.sab.2019.105654 |
| Popis: | Single particle inductively coupled plasma mass spectrometry (SP-ICP-MS) was evaluated and validated as a qualitative method for the assessment of the presence/absence of particles containing specific elements in a sample. The binary response (present/absent) obtained allows to use SP-ICP-MS as a screening tool for rapid classification of samples, which can be further submitted to more specific analysis. A metrological treatment of SP-ICP-MS as qualitative method is presented, providing solid criteria for identifying particle events in SP-ICP-MS measurements and the presence of particle in the samples by using the critical value (or limit of decision) concept. Based on theoretical and experimental evidences, a critical value for identification of particle events by using a 5σ criterion (σ: standard deviation of the baseline) is proposed to eliminate or minimize the occurrence of false positives, whereas a 2.33σ criterion (σ: standard deviation of the number of particles counted in blanks) is proposed for confirming the presence of particles larger than the minimum detectable size in a sample. Signal domain critical values can provide semiquantitative information as size and number concentration critical values. Size critical values of 25–30 nm were obtained for metallic, spherical and solid particle of gold and silver and 50–80 nm for aluminium, whereas number concentration critical values around 105 particles per liter could be achieved regardless the element for the total acquisition time selected (1 min). The screening approach was applied to the detection of particles from approved metallic additives in foods. |
| Databáze: | OpenAIRE |
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