Vergleich des Plasminogenaktivators vom Urokinasetyp (uPA) und des Plasminogenaktivator-Inhibitors (PAI-1) mit klinischen Parametern beim resezierten Plattenepithelkarzinom der Mundh�hle
| Autor: | Schmitt M, K. P. Bock, P. Dettmar, B. Hundsdorfer, H.-H. Horch, H.-F. Zeilhofer |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Mouth neoplasm
Urokinase Oncology Pathology medicine.medical_specialty business.industry Mucous membrane medicine.disease Primary tumor chemistry.chemical_compound medicine.anatomical_structure Otorhinolaryngology chemistry Plasminogen activator inhibitor-1 Internal medicine Adjuvant therapy Medicine Lymph Oral Surgery business Lymph node medicine.drug |
| Zdroj: | Mund-, Kiefer- und Gesichtschirurgie. 8:180-190 |
| ISSN: | 1434-3940 1432-9417 |
| DOI: | 10.1007/s10006-003-0519-3 |
| Popis: | This article examines the distribution and prognostic importance of urinase type plasminogen activators (uPA) and of plasminogen activator inhibitors (PAI-1) in cases of primary oral squamous cell carcinoma. Tissue from the primary tumor was taken from 79 patients. In order to make an intra-individual comparison, tissue from the healthy mucous membrane of the mouth was taken from 50 patients and metastatic tissue from lymph glands in the neck from 16 patients. The content of uPA and PAI-1 was determined using ELISA. After follow-up, 58 patients with primary surgical therapy were included. Statistical evaluation was carried out using the Kruskal-Wallis test, the Mann-Whitney U-test and the Wilcoxon test. Pearson's product moment correlation was used to determine the relationship between uPA and PAI-1 levels. The median uPA value was 3.43 ng/mg in primary tumor, and for PAI-1 47.1 ng/mg ( n=79). There was a significant correlation between uPA and PAI-1 both in the cancerous as well as the healthy tissue ( P 58 years), the older patients had higher uPA ( P |
| Databáze: | OpenAIRE |
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