Implication de la voie PI3K/Akt dans le cancer de la prostate. Nouvelles stratégies pour concevoir des thérapies ciblées
| Autor: | N. Pommery, J.-P. Hénichart |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Pharmacology
medicine.medical_specialty biology Tumor suppressor gene business.industry Farnesyltransferase Pharmaceutical Science medicine.disease Prostate cancer Endocrinology Growth factor receptor Internal medicine medicine biology.protein Cancer research PTEN Signal transduction business Tyrosine kinase PI3K/AKT/mTOR pathway |
| Zdroj: | Annales Pharmaceutiques Françaises. 63:69-75 |
| ISSN: | 0003-4509 |
| Popis: | Because of the unavailability of effective therapies to block or reverse the progression of androgen-independent prostate cancer, it seems obvious to target growth signaling pathways for which frequently recurring mutations have been identified. Acquired mutations of the PTEN gene have been reported in several tumor types, including up to 30% - 60% of prostate cancer tumors. This results in constitutive activation of the PI3K/Akt pathway which then represents a major target to prevent dysfunctions in cell growth, survival and motility. Our experience and, therefore, our own tools allow us to design new inhibitors of growth factor receptor tyrosine kinase, PDK-1 and farnesyltransferase activities. These original compounds could selectively switch off one or several steps of the multifunctional pathway and constitute lead compounds in the design of new classes of potent drugs. |
| Databáze: | OpenAIRE |
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