An integrated gas-liquid droplet microfluidic platform for digital sampling and detection of airborne targets
| Autor: | Carlos Hidrovo, Pooyan Tirandazi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Analyte
Materials science 010401 analytical chemistry Microfluidics Detector Metals and Alloys Ranging Nanotechnology 02 engineering and technology 021001 nanoscience & nanotechnology Condensed Matter Physics Chip 01 natural sciences 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Physics::Fluid Dynamics Breath gas analysis 13. Climate action Materials Chemistry Electrical and Electronic Engineering Microreactor 0210 nano-technology Absorption (electromagnetic radiation) Instrumentation |
| Zdroj: | Sensors and Actuators B: Chemical. 267:279-293 |
| ISSN: | 0925-4005 |
| DOI: | 10.1016/j.snb.2018.03.057 |
| Popis: | The use of microfluidic droplets has become ubiquitous in many Lab-on-a-Chip (LOC) applications ranging from material synthesis to novel biochemical sensing. In this paper, we introduce a new droplet-based approach that incorporates a gas phase for generating liquid droplet microreactors in a microfluidic flow-focusing format. We demonstrate the subsequent on-chip transition, collection and handling of the droplets in a secondary liquid carrier inside a multilayer PDMS structure. The presented technique has potential applications in capturing and probing airborne particles and gaseous vapors using high surface-to-volume picoliter droplets. The discrete microfluidic gas-liquid interfaces created in this approach, greatly facilitate absorption and up-concentration of a gaseous target analyte into the droplet volume. The chip-based format of the units also allows for different microfluidic modules and analytical techniques to be integrated in this platform for droplet probing, providing highly-sensitive LOC detection systems. Here, we demonstrate the basic principles of sample partitioning with gas-liquid droplets by capturing and detection of vaporized ammonia at different gaseous concentrations using Nessler’s reaction inside the droplets. The results of this work provide a simple and robust quantification approach for determining gaseous ammonia which can be further expanded to other gas-phase analytes in next generation of airborne target detectors for human breath analysis and environmental monitoring. |
| Databáze: | OpenAIRE |
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