Periocular cutaneous oncocytoma with signs of disrupted oxygen metabolism

Autor: Sebastian Haferkamp, Eva Geissinger, Hermann Kneitz, Andrea Pfister, Arno Rütten, Matthias Goebeler, Marion Wobser, Tina Giner, Sabine Roth, Tobias Meyer-ter-Vehn
Rok vydání: 2013
Předmět:
Zdroj: Journal of Cutaneous Pathology. 40:1054-1058
ISSN: 0303-6987
DOI: 10.1111/cup.12223
Popis: Oncocytomas are benign tumors most often occurring in salivary or lacrimal glands and thyroid tissue. As cutaneous oncocytoma is exceptionally rare, this tumor is uncommonly encountered by dermatopathologists. Herein, we illustrate the case of an 80-year-old man who presented with a slowly growing papule of the lower eyelid. Histopathologically, the adenomatous tumor was composed of large monomorphic cells with eosinophilic granular cytoplasm. Electron microscopy revealed abundant, enlarged and abnormally shaped mitochondria. These findings were consistent with an oncocytoma of the skin. The presented case is unique in that the thorough work-up of the tumor tissue revealed not only hyperplastic mitochondria, representing the ultrastructural correlate of the observed granular cytoplasm, but additionally disclosed functional consequences with elevated levels of reactive oxygen specimen (ROS) within the tumor. Disrupted oxygen metabolism may result from cellular aging processes and may putatively represent the underlying pathogenesis of oncocytoma.
Databáze: OpenAIRE
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