Changes in Oxygen Consumption and Phagocytosis in Rat Pulmonary Macrophages Related to Animal Maturation

Autor:	Anne P. Autor, Maureane Hoffman
Rok vydání:	1980
Předmět:	Pulmonary and Respiratory Medicine Colony-forming unit Phagocytosis Clinical Biochemistry chemistry.chemical_element Biology Oxygen Yeast Andrology Pulmonary Macrophages chemistry Immunology Molecular Biology Intracellular
Zdroj:	Experimental Lung Research. 1:313-322
ISSN:	1521-0499 0190-2148
DOI:	10.3109/01902148009069651
Popis:	Differences in selected metabolic and functional parameters of pulmonary macrophages have been found in cells obtained from rats between birth and 40 days of age. Oxygen consumption ranged from 0.6–0.8 nM/106 viable macrophages/min in the pulmonary macrophages of rats from birth to 20 days of age whereas it was 1.4–1.5 nM/106 viable macrophages/min in the pulmonary macrophages of rats 40 days of age and older. One functional test of phagocytosis which measured the combined effects of bacterial ingest ion and killing by macrophages showed that after identical treatment and exposure conditions macrophages from rats less than 15 days of age contained significantly greater numbers of live intracellular colony forming units of Staphy-lococcus aureus than did macrophages from adult rats. A second test of function in which the number of killed Saccharomyces cerevisiae ingested by macrophages was also compared on the basis of animal age indicated that the number of killed yeast ingested was higher in macrophages ...
Databáze:	OpenAIRE
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