Growth to Age 18 Months Following Prenatal Supplementation with Docosahexaenoic Acid Differs by Maternal Gravidity in Mexico
| Autor: | L M Neufeld, Meng Wang, Reynaldo Martorell, Aryeh D. Stein, Juan A Rivera, Usha Ramakrishnan, Rafael Flores-Ayala |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Pregnancy Nutrition and Dietetics business.industry Offspring Obstetrics Population Medicine (miscellaneous) Prenatal care medicine.disease Pregnancy rate Endocrinology Docosahexaenoic acid Internal medicine Medicine Gestation business education Unsaturated fatty acid |
| Zdroj: | The Journal of Nutrition. 141:316-320 |
| ISSN: | 0022-3166 |
| DOI: | 10.3945/jn.110.128215 |
| Popis: | Little is known about the long-term effects of DHA intake during pregnancy. Offspring of primagravid Mexican women who received 400 mg/d DHA from wk 20 of gestation through delivery were heavier and had larger head circumferences at birth than children whose mothers received placebo; no effect was observed in offspring of multigravidae. We have followed these children (n = 739; 76% of the birth cohort), measuring length, weight, and head circumference at 1, 3, 6, 9, 12, and 18 mo. At 18 mo, intent-to-treat differences between placebo and DHA, adjusted for maternal height and child sex and age at measurement, were: length, -0.21 cm (95% CI = -0.58, 0.15); weight, -0.03 kg (95% CI =-0.19, 0.13); and head circumference, 0.02 cm (95% CI = -0.18, 0.21) (all P > 0.05). There was heterogeneity of associations by maternal gravidity for weight (P 0.5). Maternal DHA supplementation during the second half of gestation may enhance growth through 18 mo of children born to primagravid women. |
| Databáze: | OpenAIRE |
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