SEPARATION AND DETERMINATION OF ALKYLFURYLSILANE ISOMERS FOR HPLC

Autor:	Elżbieta Bombik, Mariusz Kluska, Nikolai Erchak, Ewa Witkowska-Krajewska
Rok vydání:	2010
Předmět:	Dimethylsilane Chromatography Silica gel Aryl Clinical Biochemistry Pharmaceutical Science Biochemistry High-performance liquid chromatography Analytical Chemistry Hexane chemistry.chemical_compound chemistry Yield (chemistry) Phase (matter) Dichloromethane
Zdroj:	Journal of Liquid Chromatography & Related Technologies. 33:704-711
ISSN:	1520-572X 1082-6076
DOI:	10.1080/10826071003608918
Popis:	In this paper are presented optimal conditions of chromatographic separation of two isomers: γ-(chloropropyl)-3-furyldimethylsilane and [2-chloro(1-methyl)ethyl](3′-furyl)dimethylsilane. These isomers show the ability of modification of the surface of silica gel. In the investigation were tested three stationary phases and three mobile phases: dichloromethane, methanol, and a mixture of dichloromethane and hexane (80/20, v/v), in different flow intensities. An application of octadecyl stationary phase, which is recommended as a standard phase, did not yield separation of the isomers, independently of composition and flow of a mobile phase. Better results, but with asymmetric peaks have been obtained on the octyl phase. Finally, aryl chemically bonded phases permitted acquiring good separation of the isomers in a time shorter than 25 min. The best separation factor (1.11) has been obtained on the chemically bonded aryl phase using dichloromethane with flow of 0.1 mL · min−1. Therefore, the best selectivity...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a9065fae2934167ac378491648596a16 https://doi.org/10.1080/10826071003608918 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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