| Autor: |
Celestino Sardu, Maria Consiglia Trotta, Biagio Santella, Nunzia D' Onofrio, Michelangela Barbieri, Maria Rosaria Rizzo, Ferdinando Carlo Sasso, Lucia Scisciola, Fabrizio Turriziani, Michele Torella, Michele Portoghese, Francesco Loreni, Simone Mureddu, Maria Antonietta Lepore, Massimiliano Galdiero, Gianluigi Franci, Veronica Folliero, Arianna Petrillo, Lara Boatti, Fabio Minicucci, Ciro Mauro, Paolo Calabrò, Marisa De Feo, Maria Luisa Balestrieri, Danilo Ercolini, Michele D' Amico, Giuseppe Paolisso, Marilena Galdiero, Raffaele Marfellla |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
Objectives. We examined the association of the coronary thrombus microbiota and relative metabolites with major adverse cardiovascular events (MACE) in hyperglycemic patients with ST segment elevation myocardial infarction (STEMI).Background. Hyperglycemia during STEMI may affect both development and progression of coronary thrombus via gut and thrombus microbiota modifications. Methods. We undertook an observational cohort study of 146 first STEMI patients treated with primary percutaneous coronary intervention (PPCI) and thrombus-aspiration (TA). Patients were clustered, based on admission blood glucose levels, in hyperglycemic (>140 mg/dl) and normoglycemic (Prevotellaspp and TMAO terziles and MACE. MACE endpoint at 1 year included death, re-infarction, unstable angina.Results. In fecal and thrombus samples, we observed a significantly different prevalence of both Prevotellaspp and Alistipesspp. between patients with hyperglycemia (n=56) and those with normal glucose levels (n=90). The abundance of Prevotella increased in hyperglycemic vs normoglycemic patients whereas the contrary was observed for Alistipes. Interestingly, in coronary thrombus, the content of Prevotella was associated with admission blood glucose levels (pPrevotella and TMAO in coronary thrombus as compared to patients with low levels of Prevotella and TMAO, after 1-year follow up.Conclusions. Hyperglycemia during STEMI may increase coronary thrombus burden via gut and thrombus microbiota dysbiosis characterized by an increase of Prevotella and TMAO content in thrombi. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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