Isolation and Structural elucidation of novel bioactive moleculeCoumarin from traditionally used Medicinal Plant- Ceropegia juncea (Roxb.)

Autor:	Subhash Chandran K.P, Veraiah K, Sudha Karayil, P S Sudeesh
Rok vydání:	2014
Předmět:	chemistry.chemical_compound biology Stereochemistry Chemistry Molecule Asclepiadoideae heterocyclic compounds Biological activity biology.organism_classification Ceropegia juncea Spectral data Coumarin
Zdroj:	IOSR Journal of Pharmacy and Biological Sciences. 9:19-22
ISSN:	2278-3008 2319-7676
DOI:	10.9790/3008-09321922
Popis:	Coumarins have attracted the attention in recent years because of their diverse pharmacological properties and these diverse properties are mainly due to their structural variability and types of substitutions in their basic structure. Ceropegia juncea (Roxb.) is the plant, which belongs to the Asclepiadoideae, a subfamily belongs to the family Apocyanaceae was selected and investigated for its phytocompounds especially coumarin compounds. There was limited work on biologically active molecule, coumarin in the selected medicinal plant Ceropegia juncea (Roxb.). A novel coumarin, (E)-5-(4-methyl-2-oxo-2H-chromen-8-yl)-2-(4-methylbenzyl)-3- oxopent-4-enenitrile was isolated and the structure of the compound is studied by spectral data. Biological functions of coumarins depend on their functional groups attached. 7-hydroxy and methyl coumarins exhibit dynamic therapeutical properties. In the present study, methyl coumarin is obtained from the plant extract. Further pharmacological activities have to be studied for this novel compound for future drug lead.
Databáze:	OpenAIRE
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