Ocular Manifestations of Adult T-cell Leukemia/Lymphoma
| Autor: | Masahiro Kikuchi, Morishige Takeshita, Shigeru Fukushima, Hitomi Uchida, Toshihiko Kohno, Hajime Inomata |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Pathology
medicine.medical_specialty genetic structures business.industry Eye disease Retinitis medicine.disease eye diseases Adult T-cell leukemia/lymphoma Lymphoma Ophthalmology Leukemia immune system diseases hemic and lymphatic diseases medicine sense organs Acute retinal necrosis business Vasculitis Retinopathy |
| Zdroj: | Ophthalmology. 100:1794-1799 |
| ISSN: | 0161-6420 |
| DOI: | 10.1016/s0161-6420(13)31398-0 |
| Popis: | Background: Adult T-cell leukemia/lymphoma (ATLL) is a recently described distinct clinicopathologic entity characterized by an extremely aggressive clinical course, a leukemic or lymphomatous proliferation of hyperlobulated peripheral T cells, and an association with infection by a retrovirus, human T-Iymphotropic virus type I (HTLV-I). The authors present a patient with ATLL who initially had clinical features of severe uniocular intraocular inflammation, simulating acute retinal necrosis or herpetic retinitis, but results of histopathologic examination of the globe showed ATLL. Patient: A 38-year-old man had severe unilateral intraocular inflammation associated with widespread diffuse retinitis. Two weeks later, a focal retinitis with vasculitis developed nasal to the optic disc in the opposite eye. Shortly thereafter, mental disturbance developed, and the patient died less than 3 months after onset of the ocular symptoms. Results: Results of postmortem examination showed atypical lymphocytic infiltration in the eyes, brain, and other systemic organs. Results of histopathologic and immunohistochemical studies showed that the atypical cells infiltrating the ocular tissues were ATLL cells. Conclusions: Patients infected with HTLV-I initially can have intraocular T-cell lymphoma that simulates acute retinal necrosis or herpetic retinitis. |
| Databáze: | OpenAIRE |
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