A novel synthetic approach to glycerophospholipids via Horner–Wadsworth–Emmons reaction of mixed phosphonoacetate

Autor:	Hayato Sumiyoshi, Shigeki Sano, M. Nakao, Atsushi Handa, Rie Tokizane
Rok vydání:	2015
Předmět:	Phosphatidylethanolamine Organic Chemistry Horner–Wadsworth–Emmons reaction Phosphatidic acid Glycerophospholipids Biochemistry chemistry.chemical_compound chemistry Reagent Phosphatidylcholine Drug Discovery Glycerophospholipid Organic chemistry Common key
Zdroj:	Tetrahedron Letters. 56:4686-4688
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2015.06.033
Popis:	A novel synthetic approach to glycerophospholipids featuring the use of Horner–Wadsworth–Emmons reagents as masked glycerophospholipids has been developed. Based on this method, phosphatidic acid (PA), phosphatidylethanolamine (PE), and phosphatidylcholine (PC) containing palmitoyl moieties were readily synthesized from a mixed phosphonoacetate as a common key intermediate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a8d5e39a7de94ba1dbba430657428ed4 https://doi.org/10.1016/j.tetlet.2015.06.033 Zobrazit plný text záznamu Full Text from ScienceDirect