Chemical characteristics of Staphylococcus aureus molecules that have CD14-dependent cell-stimulating activity

Autor:	T Kusunoki, S D Wright
Rok vydání:	1996
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 157:5112-5117
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.157.11.5112
Popis:	We have previously shown that Staphylococcus aureus contains molecules that bind CD14 and induce cellular responses. We have partially purified this activity and named the product active fraction (AF). Here, we further explore the chemical characteristics of AF. We show that 1) the activity is sensitive to base and hydrofluoric acid hydrolysis; 2) AF binds to Mono Q, indicating that it is negatively charged; 3) most activity in AF runs as a large species in aqueous buffer, but a small proportion runs with a size of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a8d20f488c04ca12d783617735b34ff6 https://doi.org/10.4049/jimmunol.157.11.5112 Zobrazit plný text záznamu