The Sigma-1 Receptor Ligand Chlorpromazine Attenuates Store-Dependent Ca2+ Entry in Peritoneal Macrophages
| Autor: | Z. I. Krutetskaya, V. G. Antonov, N. I. Krutetskaya, L. S. Milenina |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Thapsigargin Sigma-1 receptor 030102 biochemistry & molecular biology Chemistry medicine.drug_class Endoplasmic reticulum Biophysics Ligand (biochemistry) Receptor antagonist Cell biology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology medicine Chlorpromazine Cyclopiazonic acid Receptor medicine.drug |
| Zdroj: | Biophysics. 66:77-83 |
| ISSN: | 1555-6654 0006-3509 |
| DOI: | 10.1134/s0006350921010115 |
| Popis: | Using Fura-2AM, a fluorescent Ca2+ indicator, we have shown for the first time that sigma-1 receptor antagonist - neuroleptic chlorpromazine - significantly inhibits the store-dependent Ca2+ entry induced by immunomodulators glutoxim as well as molixan and endoplasmic reticulum Са2+-ATPase inhi-bitors thapsigargin and cyclopiazonic acid in rat peritoneal macrophages. The results suggest the involvement of sigma-1 receptors in the regulation of store-dependent Ca2+ entry in macrophages. |
| Databáze: | OpenAIRE |
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