Photodynamic inheritance from methylene blue to carbon dots against reduction, aggregation, and DNA interference
| Autor: | Wen Sun, Haoying Ge, Jiangli Fan, Quanyong Gu, Xiaojun Peng, Jianjun Du, Saran Long, Ning Xu |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Biocompatibility medicine.medical_treatment Photodynamic therapy 02 engineering and technology Photosensitizing Agent 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences In vitro 0104 chemical sciences chemistry.chemical_compound chemistry In vivo Cancer cell medicine Biophysics General Materials Science 0210 nano-technology DNA Methylene blue |
| Zdroj: | Science China Materials. 64:2325-2336 |
| ISSN: | 2199-4501 2095-8226 |
| Popis: | Photodynamic therapy (PDT) is a treatment that uses light-sensitive drugs and a light source to destroy cancer cells. Methylene blue (MB) is an efficient photosensitizing agent that has been widely used in PDT. However, MB suffers from the hypochromic effect that is caused by self-aggregation and DNA binding in vivo. It is also easily reduced to ineffective leucomethylene blue in the hypoxic environments surrounding solid tumors. In this work, we prepared MB carbon dots (MB-CDs) using MB as the carbon source. The MB-CDs not only inherit the PDT capabilities of MB, but also demonstrate good biocompatibility and low toxicity. Importantly, MB-CDs demonstrate excellent resistance to interference from reduction, aggregation, and DNA interactions. The MB-CDs exhibited satisfactory PDT activities both in vitro and in vivo. The tumor sizes were reduced to below 20% of their original volumes when irradiated by a 590-nm light-emitting diode source. |
| Databáze: | OpenAIRE |
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