Dual-core@shell-structured Fe3O4–NaYF4@TiO2 nanocomposites as a magnetic targeting drug carrier for bioimaging and combined chemo-sonodynamic therapy
| Autor: | Yanru Ge, Meng Wang, Fenfen Kong, Haijun Shen, Lin Wu, Meng Xie, Xiaomeng Guo, Song Shen, Yi Jin, Xinshi Wang |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Chemotherapy Nanocomposite Materials science medicine.medical_treatment Sonodynamic therapy Biomedical Engineering General Chemistry General Medicine Surgery chemistry.chemical_compound chemistry Apoptosis Hyaluronic acid medicine Cancer research General Materials Science Doxorubicin Drug carrier Dual core medicine.drug |
| Zdroj: | J. Mater. Chem. B. 2:5775-5784 |
| ISSN: | 2050-7518 2050-750X |
| DOI: | 10.1039/c4tb00841c |
| Popis: | Multifunctional dual-core@shell (Fe3O4–NaYF4@TiO2) nanocomposite (DCSNC) loaded with doxorubicin (DOX) have been developed for synergetic sonodynamic cancer chemotherapy, where titanium dioxide (TiO2) is employed as a sonosensitizer for sonodynamic therapy (SDT) of the tumor in deep tissues, and NaYF4 is used for upconversion luminescence (UCL) imaging. After being coated with hyaluronic acid (HA), the nanocomposites exhibit a time dependent cellular uptake and an excellent nucleus targeting effect in KB and MCF-7 cells. The ultrasound of HA–DCSNCs obviously enhances the apoptosis rate of MCF-7 cells. A greater tumor inhibition rate is observed when the tumor-bearing mice are treated with combined therapy (88.36%) compared with chemotherapy (28.36%) or sonodynamic therapy (38.91%) alone, indicating the potential of sonodynamic chemotherapy for cancer treatment. |
| Databáze: | OpenAIRE |
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