Fabrication of novel bioceramic α-Fe2O3/MnO nanocomposites: Study of their structural, magnetic, biocompatibility and antibacterial properties
| Autor: | Debananda Mohapatra, Mayank Bhushan, Annamraju Kasi Viswanath, Yogesh Kumar |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Nanocomposite Materials science biology Biocompatibility medicine.drug_class Mechanical Engineering Composite number Antibiotics 02 engineering and technology Bioceramic 021001 nanoscience & nanotechnology Condensed Matter Physics biology.organism_classification Nanomaterials 03 medical and health sciences Chemical engineering Mechanics of Materials medicine General Materials Science 0210 nano-technology Bacteria 030304 developmental biology Superparamagnetism |
| Zdroj: | Materials Science and Engineering: B. 268:115119 |
| ISSN: | 0921-5107 |
| Popis: | In recent times, a sharp increase in prevalence of bacterial strains showing resistance against currently used antibiotics has severely challenged the modern healthcare system in the treatment of bacterial infections. Therefore, it is needed to find suitable alternatives to counter this problem in order to treat contagious diseases. Nanomaterials/composites based inorganic antibiotic appears to be a feasible option, because these materials kill bacteria by concurrently acting through multiple mechanisms, unlike traditional antibiotics. In this study, Fe/Mn oxide nanocomposites were synthesized via a wet-chemical approach, and well characterized to examine their structural, dimensional, elemental, magnetic, cytotoxic and, antibacterial attributes. The nanocomposites exhibited mixed phases of constituent metal oxides α-Fe2O3 and MnO. The composite samples were of rod shape and shown room temperature superparamagnetism. Further, the prepared samples were found compatible with the cell lines MCF7 and MCF-12A, and exhibited ROS induced excellent bactericidal properties against bacteria E. coli, B. subtilis, S. aureus, and S. typhi. Therefore, the Fe/Mn oxide nanocomposites have the potential to become a promising alternative to the traditional antibiotics. |
| Databáze: | OpenAIRE |
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