Chondrogenesis in chick embryo somites in vitro

Autor:	M. L. Ellison, E. J. Ambrose, G. C. Easty
Rok vydání:	1969
Předmět:	Mesoderm animal structures Cartilage Embryogenesis Embryo Anatomy Biology Chondrogenesis Spinal cord Somite medicine.anatomical_structure embryonic structures Notochord medicine Molecular Biology Developmental Biology
Zdroj:	Development. 21:331-340
ISSN:	1477-9129 0950-1991
DOI:	10.1242/dev.21.2.331
Popis:	During the embryonic development of vertebral cartilages, cells from the somite mesoderm differentiate into chondrocytes around the spinal cord and notochord. Grafting experiments in amphibian and chick embryos have indicated that the spinal cord and notochord have some influence on this differentiation of somite cells to cartilage (Holtzer & Detwiler, 1953; Watterson, Fowler & Fowler, 1954). Further analysis in vitro has established that, under specified culture conditions, cartilage formation from somites is, in fact, dependent on the presence of either spinal cord and/or notochord or their extracts (Grobstein & Parker, 1954; Grobstein & Holtzer, 1955; Strudel, 1962, 1963; Lash, 1963). For example, Lash (1963) showed that in his system on a liquid medium stage 16 (Hamburger & Hamilton, 1951, stages) somites alone formed no cartilage, but that cartilage did develop when notochord or spinal cord was cultured with the somites. This suggested that the spinal cord and notochord were ‘inducing’ somite mesoderm cells to form chondrocytes.
Databáze:	OpenAIRE
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