Fine Needle Aspiration Cytology of Adrenocortical Oncocytic Neoplasm

Autor:	Robert A. Goldschmidt, Lin Liu, William G. Watkin, Elaine Cham
Rok vydání:	2010
Předmět:	medicine.medical_specialty Pathology Histology medicine.diagnostic_test Adenoma business.industry General Medicine Adrenal Cortex Neoplasm Malignancy medicine.disease Pathology and Forensic Medicine Fine-needle aspiration Biopsy Eosinophilic medicine Oncocytic Neoplasm Radiology Fibroma business
Zdroj:	Acta Cytologica. 54:627-634
ISSN:	1938-2650 0001-5547
DOI:	10.1159/000325190
Popis:	Background Adrenocortical oncocytic neoplasms (AONs) are rare tumors that typically show marked nuclear pleomorphism and eosinophilic cytoplasm and are highly cellular on fine needle aspiration (FNA) smears. These features, worrisome in conventional adrenocortical tumors, are not necessarily signs of malignancy in AONs. Case A 64-year-old woman presented with 3 months of abdominal pressure. Computed tomography showed a 10-cm, solid, left adrenal mass and a 21-cm complex cystic mass in the pelvis. FNA of the adrenal mass showed hypercellular smears with dyscohesive cells having pleomorphic nuclei and abundant, granular cytoplasm. The lesion was initially interpreted as malignant. Resection of the adrenal mass demonstrated an AON without definite malignant features. The pelvic mass revealed bilateral ovarian cellular fibromas. Seventeen months of postoperative follow-up were uneventful. Conclusion On FNA, cells from an AON can be hypercellular and cytologically atypical, which can be pitfalls for a malignant diagnosis. Our case is the first reported in which an AON presented with ovarian cellular fibromas. To our knowledge, there is no association between the 2 lesions. We review criteria to classify benign vs. malignant AONs and discuss the literature on this topic.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a8c121495bbfeb9f58f3d573ab4185a3 https://doi.org/10.1159/000325190 Zobrazit plný text záznamu