Resolution of chiral [2.2]paracyclophanes by enantioselective gas chromatography
| Autor: | Wilfried A. König, Henning Hopf, Bärbel Gehrcke, Detlev H. Hochmuth, Cornelia Mlynek |
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| Rok vydání: | 1994 |
| Předmět: |
chemistry.chemical_classification
Cyclodextrin Stereochemistry Organic Chemistry Enantioselective synthesis Substituent Ring (chemistry) Medicinal chemistry Catalysis Inorganic Chemistry chemistry.chemical_compound chemistry Gas chromatography Physical and Theoretical Chemistry Enantiomer Benzene Cyclophane |
| Zdroj: | Tetrahedron: Asymmetry. 5:347-350 |
| ISSN: | 0957-4166 |
| DOI: | 10.1016/s0957-4166(00)86203-5 |
| Popis: | [2.2]Paracyclophanes possessing a substituent on the aromatic ring are dissymmetric compounds due to the restricted rotation of the benzene rings. For interconversion of enantiomers temperatures above 200 °C are necessary. We have succeeded in resolving the enantiomers of some mono-substituted [2.2]paracyclophanes by enantioselective gas chromatography using 2,3-di-O-methylated β-cyclodextrins with bulky O-(1,1,2-trimethylpropyl)-dimethylsilyl or O- t .butyl-dimethylsilyl substituents in the 6-position of the glucose units as chiral stationary phases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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