The Development of a Large-Scale Synthesis of Matrix Metalloproteinase Inhibitor, ABT-518
Autor: | Michael G. Fickes, Zhenping Tian, Shyamal Parekh, Todd S. Mcdermott, Sou-Jen Chang, Steven J. Wittenberger, Ashok K. Gupta, Dilinie P. Fernando, David R. Hill |
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Rok vydání: | 2002 |
Předmět: | |
Zdroj: | Organic Process Research & Development. 6:329-335 |
ISSN: | 1520-586X 1083-6160 |
Popis: | A process for the preparation of matrix metalloproteinase inhibitor ABT-518 has been developed. Significant improvements have been made to the first generation synthesis and are described here. The new process is very robust and efficient; multikilogram quantities of the title compound have been synthesized for clinical trials. ABT-518 was prepared by this six-step synthetic sequence in 51% overall yield with >99% ee. |
Databáze: | OpenAIRE |
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