Interferon λ3 gene (IL28B) is associated with spontaneous or treatment-induced viral clearance in hepatitis C virus-infected multitransfused patients with thalassemia
| Autor: | Debanjali Gupta, Provash Chandra Sadhukhan, Prosanto Chowdhury, Maitreyee Bhattacharyya, Kallol Saha, Monika Ghosh, Aritra Biswas, Rushna Firdaus |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Hepatitis C virus Thalassemia Immunology Population medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Interferon Genotype Immunology and Allergy Medicine Allele education Genotyping education.field_of_study business.industry Hematology medicine.disease Virology 030104 developmental biology 030211 gastroenterology & hepatology Gene polymorphism business medicine.drug |
| Zdroj: | Transfusion. 57:1376-1384 |
| ISSN: | 0041-1132 |
| DOI: | 10.1111/trf.14070 |
| Popis: | BACKGROUND Hepatitis C virus (HCV) is the major posttransfusion infection in multitransfused individuals in India with thalassemia major. To our knowledge, this study is the first conducted to correlate and comprehend the effects of the host interleukin (IL)28B gene polymorphism at loci rs12979860 and rs8099917 in spontaneous or interferon (IFN)-induced treatment response in the HCV-seroreactive individuals with thalassemia major. STUDY DESIGN AND METHODS A total of 557 HCV-seroreactive individuals with thalassemia were processed for HCV viral genotyping and host IL28B single-nucleotide polymorphism analysis at loci rs12979860 and rs8099917. RESULTS Of 557 individuals, 70.92% were found to be HCV RNA positive with Genotype 3 (95.18%) as predominant strain. A favorable CC allele at locus rs2979860 and TT allele at rs8099917 were 75.31 and 77.16%, respectively, which was strongly associated with spontaneous clearance of infection (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text