DNA Polymorphisms in SREBF1 and FASN Genes Affect Fatty Acid Composition in Korean Cattle (Hanwoo)
| Autor: | D. Yoon, S. L. Yu, N. K. Kim, Y. M. Cho, M. S. A. Bhuiyan, J. T. Jeon, E. W. Park, Jun Heon Lee, Kwan-Suk Kim |
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| Rok vydání: | 2009 |
| Předmět: |
chemistry.chemical_classification
Linoleic acid food and beverages Fatty acid Biology Palmitic acid chemistry.chemical_compound Oleic acid Fatty acid synthase chemistry Biochemistry Hanwoo biology.protein lipids (amino acids peptides and proteins) Animal Science and Zoology Stearic acid Food Science Polyunsaturated fatty acid |
| Zdroj: | Asian-Australasian Journal of Animal Sciences. 22:765-773 |
| ISSN: | 1976-5517 1011-2367 |
| DOI: | 10.5713/ajas.2009.80573 |
| Popis: | Sterol regulatory element binding factor 1 (SREBF1) and fatty acid synthase (FASN ) genes play an important role in the biosynthesis of fatty acids and cholesterol, and in lipid metabolism. This study used polymorphisms in the intron 5 of bovine SREBF1 and in the thioesterase (TE) domain of FASN genes to evaluate their associations with beef fatty acid composition. A previously identified 84-bp indel (L: insertion/long type and S: deletion/short type) of the SREBF1 gene in Korean cattle had significant associations with the concentration of stearic (C18:0), linoleic (C18:2) and polyunsaturated fatty acids (PUFA). The stearic acid concentration was 6.30% lower in the SS than the LL genotype (p A, g.18043C>T, g.18440G>A, g.18529G>A and g.18663C>T in the TE domain of the FASN gene were identified among the different cattle breeds studied. Among these, only g.17924 G>A and g.18663C>T SNPs were segregating in the Hanwoo population. The g.17924G>A SNP is a non-synonymous mutation (thr2264ala) and was significantly associated with the contents of palmitic (C16:0) and oleic acid (C18:1). The oleic acid concentration was 3.18% and 2.79% higher in Hanwoo with the GG genotype than the AA and AG genotypes, respectively (p A SNP of the FASN |
| Databáze: | OpenAIRE |
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