Influence of chemical nature of carrier materials on the dissolution behavior of racemic ibuprofen
| Autor: | Miaotian Sun, Monika Johannsen, Michael Türk, Sarah Reiser |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Aqueous solution
Chromatography Chemistry organic chemicals General Chemical Engineering 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Ibuprofen 01 natural sciences 0104 chemical sciences Bioavailability Aqueous solubility medicine Physical and Theoretical Chemistry 0210 nano-technology Dissolution Particle deposition Nuclear chemistry medicine.drug |
| Zdroj: | The Journal of Supercritical Fluids. 132:91-98 |
| ISSN: | 0896-8446 |
| Popis: | The poor aqueous solubility of ibuprofen due to its hydrophobicity limits the bioavailability of the drug in the aqueous environment of the human body. Therefore particle deposition experiments were performed with ibuprofen and different carrier materials. Furthermore, the dissolution behavior of the untreated ibuprofen and the ibuprofen loaded carriers has been investigated at 310 K and pH = 2.0 and pH = 5.5. The results of this investigation demonstrate that drug loadings up to 50 wt% drug onto silica materials could be achieved and that the drug loading increases nearly linear with increasing surface area of the silica materials. Furthermore, the study reveals that the highest dissolution rate was obtained with β-cyclodextrin and that the dissolution rate of all materials investigated increases with increasing pHvalue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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