Low-dose local nasal immunotherapy in children with perennial allergic rhinitis due to Dermatophagoides

Autor: Roberto Bernardini, G. Cavagni, Francesco Marcucci, Carlo Caffarelli, G. Riva, Elio Novembre, A. Tiri, L. Sensi
Rok vydání: 2002
Předmět:
Zdroj: Allergy. 57:23-28
ISSN: 0105-4538
DOI: 10.1046/j.0105-4538.2001.00001.x-i3
Popis: Background:Allergen specific immunotherapy was known to be useful in the treatment of respiratory allergic disease. Local nasal immunotherapy (LNIT) offers advantages such as a good efficacy/safety ratio and a more convenient allergen delivery. The aim of this study was to assess the safety and clinical efficacy of a modified scheduling of LNIT in 32 children with allergic rhinitis due to Dermatophagoides. Methods:A multicentre, randomized, double-blind placebo controlled study carried out for two years, with a modified schedule of LNIT treatment: a build-up phase at increasing dosages from 2.5 AU to 80 AU and a maintenance period at low dosage (80 AU) once a week. Symptom and medication scores, threshold dose with specific nasal provocation test (NPT) and immunological parameters (IgE and IgG4) were evaluated. Results:No important local or systemic side-effects were observed in children who completed the study. Compared to placebo, the active treatment group showed significant improvement in rhinitis symptoms and a reduction of drug consumption after 18 months of LNIT. These results were confirmed by a significant reduction of allergen specific nasal reactivity. Serum and nasal specific IgE and IgG4 did not show any difference in the two groups. Conclusions:The safety and clinical efficacy of low-dose LNIT suggests that this therapy may be useful in the treatment of allergic rhinitis disease in children.
Databáze: OpenAIRE
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