PARAMETER ESTIMATION AND PREDICTION OF NONLINEAR BIOLOGICAL SYSTEMS: SOME EXAMPLES

Autor: Karel J. Keesman, T.G. Doeswijk
Rok vydání: 2006
Předmět:
Zdroj: IFAC Proceedings Volumes. 39:1156-1161
ISSN: 1474-6670
DOI: 10.3182/20060329-3-au-2901.00186
Popis: Rearranging and reparameterizing a discrete-time nonlinear model with polynomial quotient structure in input, output and parameters (xk = f(Z, p)) leads to a model linear in its (new) parameters. As a result, the parameter estimation problem becomes a so-called errors-in-variables problem for which a total least squares approach provides a natural solution. Retrieving the predictor form after estimation leads to the modified predictor: ?x = ? f(Z, ??). The objective of this paper is to evaluate the predictive quality of ?xk = ? f(Z, ??) and ?xk = f(Z, ?p) with parameters estimated using different least squares methods. The well-known Michaelis-Menten kinetics are used as an illustration with simulated (noisy) data. Finally, an example of a storage facility containing biological products is presented with real experimental data. IFAC 2006
Databáze: OpenAIRE