Duodenal gangliocytic paraganglioma with regional lymph node metastasis and a glandular component
| Autor: | Sho Ogata, Satoshi Aiko, Shinsuke Aida, Takuya Horio, Yoshiaki Sugiura |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry Lymphovascular invasion medicine.medical_treatment General Medicine Pancreaticoduodenectomy medicine.disease Primary tumor Lymphovascular Gangliocytic paraganglioma Pathology and Forensic Medicine medicine.anatomical_structure Medicine Hamartoma Lymph business Lymph node |
| Zdroj: | Pathology International. 61:104-107 |
| ISSN: | 1320-5463 |
| DOI: | 10.1111/j.1440-1827.2010.02620.x |
| Popis: | Gangliocytic paraganglioma (GP) is generally considered to be a benign periampullary lesion, although it is unclear whether it should be classified as a hamartoma or as a neoplasm. Here, we present a GP case with lymph node metastasis. A 16-year-old boy complained of exertional dyspnea. Upper endoscopy and imaging studies revealed a polypoid ampullary tumor. Pancreaticoduodenectomy with lymph node dissection was performed due to swelling of peripancreatic lymph nodes. Histologically, the tumor consisted of three cell types: epithelioid; spindle; and ganglion cells. In addition to these typical components of GP, a distinct glandular component was also present. There was substantial invasion of tumor cells into the lymphovascular vessels, associated with lymph node metastases. These lymph node metastases were histologically similar to the primary tumor. To judge from these findings GP may be a true neoplasm with metastatic capacity. Pre- and intraoperative investigations for lymph node or distant metastases are required for adequate resection of this kind of tumor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text