Comet assay application in evaluation the safe use of medicinal plants
| Autor: | L. E. Alcaráz, C. M. Mattana, Ana Mariel Mohamed, Sara E. Satorres, Laciar Al, María Alejandra Cangiano |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Acacia caven Traditional medicine biology DNA damage Prosopis torquata Moderate level medicine.disease_cause biology.organism_classification Applied Microbiology and Biotechnology Toxicology Comet assay 03 medical and health sciences 030104 developmental biology medicine Animal Science and Zoology Acacia furcatispina Medicinal plants Agronomy and Crop Science Genotoxicity Food Science |
| Zdroj: | Emirates Journal of Food and Agriculture. 28:737 |
| ISSN: | 2079-052X |
| Popis: | Genotoxicity of three aqueous extracts obtained of Acacia caven (espinillo), Acacia furcatispina (garabato) and Prosopis torquata (tintitaco), was evaluated by comet assay. Three concentrations (0.1; 10 and 20 mg/mL to A. cavens and A. furcatispina; 0.2; 2 and 20 mg/mL to P. torquata) were tested and the damage index for each was calculated. Based on the results, it was determined that both aqueous extracts of A. cavens and A. furcatispina showed no damage DNA at 0.1 and 10 mg/mL but, at 20 mg/mL induced significant differences DNA primary damage in human blood peripheral cells (p< 0.05), showing moderate level damage (category 2). On the other hand, P. torquata extract was strongly genotoxic at all concentrations tested. |
| Databáze: | OpenAIRE |
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