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Purpose: Women who deliver macrosomic or big baby have been observed to sustain adverse maternal and fetal outcomes such as prolonged labor, perineal tears, uterine rupture, postpartum hemorrhage, maternal and neonatal deaths. The study aimed at assessing predictive factors associated with fetal macrosomia at a tertiary hospital in Tanzania.Methods: This was an analytical quantitative study that used a case-control study design in which cases were women who delivered babies weighing ≥ 4000g while controls were those who delivered babies weighing 2500g to 3500g. Purposive sampling technique was employed to recruit both controls and cases 216 participants. This was an unmatched case control study. A structured questionnaire was used for the data collection. SPSS version 25 software program was used for data entry and analysis.Results: The identified predictors associated with fetal macrosomia at Iringa Regional Referral hospital were advanced gestation age (AOR=8.16, CI 3.49-19.03, p=), diabetes mellitus during pregnancy (AOR =12.03, CI 1.28 -13.14, p= 0.0297) and a previous history of macrosomic baby delivery (AOR = 3.01, CI 1.02 -8.89, p=0.0467).Conclusion: women with advanced gestation age, diabetes mellitus during pregnancy, and a previous history of macrosomic baby delivery are at an increased risk of delivering a macrosomic baby. |