Effects of Glycosaminoglycans Extrat from sea Cucumber Stichopus vastus on Inflammatory Mediators and Tissue Healing on Rodents with full Thickness Burn Injury
| Autor: | Mohd Nikman Ahmad, Mohd Faeiz Pauzi, Siti Norazlina Juhari, Farid Che Ghazali |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Chemistry Angiogenesis medicine.drug_class medicine.medical_treatment 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology medicine.disease 01 natural sciences Anti-inflammatory 0104 chemical sciences Glycosaminoglycan Cytokine medicine.anatomical_structure Endocrinology Internal medicine medicine Pharmacology (medical) Integument 0210 nano-technology Fibroblast Wound healing Pharmacology Toxicology and Pharmaceutics (miscellaneous) Infiltration (medical) |
| Zdroj: | Research Journal of Pharmacy and Technology. 11:3874 |
| ISSN: | 0974-360X 0974-3618 |
| DOI: | 10.5958/0974-360x.2018.00710.2 |
| Popis: | This study was design to investigate the effect of total sulfated GAG from integument body wall of sea cucumber Stichopus vastus on inflammatory mediators and tissue healing on rodents with full thickness burn injury.Twelve male Sprague-dawley rats weighting 350-400 grams were distributed randomly into two groups. Six rats in group A received 5 ml/kg/day intraperitoneal total sulfated GAG from S.vastusfor 5 days, while control group received phosphate buffered saline (PBS). Level ofIL-10 and IL-12 were measured at day 1, 6 and 12. The level of IL-10 revealed significantly (p |
| Databáze: | OpenAIRE |
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