Mechanisms of Vertebrate Germ Cell Determination
| Autor: | Susannah H. Kassmer, Ramiro Alberio, Andrew D. Johnson, Tristan Aguero, Mary Lou King |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Regulation of gene expression Genetics Xenopus Context (language use) Biology biology.organism_classification Germline Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure medicine Germ line development Zebrafish 030217 neurology & neurosurgery Germ cell Germ plasm |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9783319460932 |
| DOI: | 10.1007/978-3-319-46095-6_8 |
| Popis: | Two unique characteristics of the germ line are the ability to persist from generation to generation and to retain full developmental potential while differentiating into gametes. How the germ line is specified that allows it to retain these characteristics within the context of a developing embryo remains unknown and is one focus of current research. Germ cell specification proceeds through one of two basic mechanisms: cell autonomous or inductive. Here, we discuss how germ plasm driven germ cell specification (cell autonomous) occurs in both zebrafish and the frog Xenopus. We describe the segregation of germ cells during embryonic development of solitary and colonial ascidians to provide an evolutionary context to both mechanisms. We conclude with a discussion of the inductive mechanism as exemplified by both the mouse and axolotl model systems. Regardless of mechanism, several general themes can be recognized including the essential role of repression and posttranscriptional regulation of gene expression. |
| Databáze: | OpenAIRE |
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