| Popis: |
Lung and liver functions are intimately related in both health and disease. Our study is an effort to detect lung function abnormality in patients of chronic liver disease. In this prospective study, 50 chronic liver disease patients of age 18 years or above underwent pulmonary function test and chest radiography as a pre-anesthesia work up for liver transplant surgery. Parameters like Forced vital capacity (FVC), Forced expiratory volume in one second (FEV1), Forced expiratory flow 75%-25% (FEF75%-25%), Maximum voluntary ventilation (MVV). Residual volume and total lung capacity (RV and TLC), Diffusion capacity (DLCO), Maximum static inspiratory and expiratory mouth pressure (MIP and MEP) were studied. Out of 50 patients, 28 patients (56%) had abnormal PFT; predominant lung function abnormality seen was restrictive defect [1], present in 21 patients (42%) which is statistically significant. Chest radiographic abnormalities were seen in 30% of chronic liver disease patients in present study. DLCO, MIP, MEP, RV, TLC were reduced compared to predicted values, however the difference is clinically not significant In Conclusion, Diagnosing lung function abnormality preoperatively may help in optimizing lung functions of chronic liver disease patients in peri-operative period. Small sample size being limitation of our study may be a larger study would help in establishing significance of association and correlation which are not statistically significant in our study. Referrences: [1] Siemieniako A, Pogorzelska J, Łapinski TW, Flisiak R. [Respiratory functional impairment in patients with liver cirrhosis]. Pol Merkur Lekarski. 2011 Nov;31(185):274-7. |
