Rhenium(I) and technetium(I) fac-M(NSO)(CO)3 (M=Re, 99mTc) tricarbonyl complexes, with a tridentate NSO bifunctional agent: Synthesis, structural characterization, and radiochemistry

Autor:	Minas Papadopoulos, Charalambos Tsoukalas, Dionysia Papagiannopoulou, George Makris, Aris Terzis, Ioannis Pirmettis, Catherine P. Raptopoulou, Maria Pelecanou
Rok vydání:	2010
Předmět:	Ligand Stereochemistry chemistry.chemical_element Carbon-13 NMR Rhenium Technetium Medicinal chemistry Inorganic Chemistry chemistry.chemical_compound Propanoic acid chemistry Yield (chemistry) Materials Chemistry Chelation Physical and Theoretical Chemistry Bifunctional
Zdroj:	Polyhedron. 29:876-880
ISSN:	0277-5387
DOI:	10.1016/j.poly.2009.10.009
Popis:	The synthesis and structural characterization of the neutral rhenium complex fac-[Re(NSO)(CO)3], Re-1, where (NSO) is a tridentate bifunctional chelating agent, 3-(carboxymethylthio)-3-(1H-imidazol-4-yl)propanoic acid (1), is presented. The complex crystallized from methanol–water and its structure was assigned by IR and 1H, 13C NMR spectroscopies and X-ray crystallography. Furthermore, the analogous technetium complex fac-[99mTc(NSO)(CO)3], 99mTc-1, was synthesized in high yield by reacting ligand 1 with the fac-[99mTc(OH2)3(CO)3]+ precursor for 30 min at 85 °C. The tracer complex was found to be more than 95% stable in the L-histidine challenge experiment. Our data indicate that the bifunctional NSO chelating agent 1 can be successfully applied for the development of potential 99mTc-radiopharmaceuticals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a8783b91ef30720587991b6c9fd0b987 https://doi.org/10.1016/j.poly.2009.10.009 Zobrazit plný text záznamu Full Text from ScienceDirect