Selective Cytotoxicity of Certain Essential Fatty Acids Towards Tumour Cells
| Autor: | M. Elliot, D.F. Horrobin, G. W. Ells, R.C. Cantrill |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
chemistry.chemical_classification
Oncogene Chemistry food and beverages Transfection eye diseases Lipid peroxidation chemistry.chemical_compound Biochemistry Essential fatty acid Second messenger system lipids (amino acids peptides and proteins) sense organs Receptor human activities Function (biology) Polyunsaturated fatty acid |
| Zdroj: | Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury ISBN: 9781461365624 |
| DOI: | 10.1007/978-1-4615-3520-1_109 |
| Popis: | Cancer cell lines in culture are susceptible to certain polyunsaturated fatty acids (PUFA). Cells expressing a transfected Ki-ras oncogene are also more sensitive to the actions of PUFA than the non- transfected parent line. One possible mechanism is lipid peroxidation, although alterations in membrane- bound receptor or second messenger function have been measured. This selectivity of PUFA is also apparent in animal models, where dietary supplementation with oils rich in PUFA causes a reduction in tumour occurrence and size. It is suggested that the use of PUFA in radiation therapy and in human cancer treatment may be a promising approach. |
| Databáze: | OpenAIRE |
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