EFFECTS OF REDUCTION OF THE 3-KETONE OF 17α-ETHYNYL-19-NORTESTOSTERONE ON ITS ENDOCRINE PROPERTIES
| Autor: | Francis J. Saunders, Ehard F. Nutting, Richard L. Elton |
|---|---|
| Rok vydání: | 1962 |
| Předmět: |
education.field_of_study
medicine.medical_specialty Genitourinary system business.industry Endocrinology Diabetes and Metabolism medicine.medical_treatment Population Uterus Estrone General Medicine Steroid chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Internal medicine medicine Endocrine system skin and connective tissue diseases Antagonism business education Hormone |
| Zdroj: | Acta Endocrinologica. 41:381-390 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.0410381 |
| Popis: | 17α-Ethynyl-4-estrene-3,17-diol and its C-3 and C-17 esterified analogues were studied for progestational, oestrogenic and androgenic properties. In addition, oestrogen-antagonistic and anti-progestational effects were determined and compared with those of 17α-ethynyl-19-nortestosterone. All of the steroids studied had progestational and oestrogen-antagonistic properties. Within the limits of the tests employed, all of the agents except 17α-ethynyl-19-nortestosterone had definite oestrogenic activity and produced antagonism of progesterone-induced proliferation of the uterine epithelium in rabbits. Thus, reduction of the 3-ketone of 17α-ethynyl-19-nortestosterone markedly alters the endocrine profile of the steroid imparting oestrogenic and anti-progestational effects in addition to the progesterone-like and oestrogen-antagonistic effects. The oestrogenic effects could be correlated with the ability of the agents to interrupt pregnancy in rats. Androgenic activity, though reduced to minimal levels, was not totally absent following these structural alterations. |
| Databáze: | OpenAIRE |
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