| Autor: |
Alberto Jorge Alves, Nir Eynon, Michael Sagiv, Ehud Goldhammer, Chen Yamin, Moran Sagiv, Yoav Meckel |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Experimental Physiology. 94:1147-1152 |
| ISSN: |
0958-0670 |
| DOI: |
10.1113/expphysiol.2009.049668 |
| Popis: |
Functional Gly482Ser (rs8192678) and T294C (rs2016520) polymorphisms in the peroxisome proliferator-activated receptor γ coactivator-1 (PPARGC1A) and peroxisome proliferatoractivated receptor δ (PPARD) genes, respectively, have been associated with mRNA and/or protein activity. The aim of this study was to determine their frequency distribution among 155 Israeli athletes (endurance athletes and sprinters) and 240 healthy control subjects. There were no differences between the endurance athletes, the sprinters and the control group across the PPARD T294C genotypes (P =0.62). Similarly, no statistical differences were found between the subgroups of elite-level endurance athletes (those who had represented Israel in a world track and field championship or in the Olympic Games) and national-level endurance athletes (P =0.3), or between elite-level and national-level sprinters (P =0.9). However, a combined influence of these two polymorphisms on endurance performance was found. The PPARD CC+PPARGC1A Gly/Gly genotypes were more frequently found in the elite endurance athletes than in national-level endurance athletes (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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