Urease-catalyzed synthesis of aminocyanopyridines from urea under fully green conditions
| Autor: | Mohammad R. Noorbala, Somayeh Ghazi, Fatemeh Tamaddon |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Urease
biology 010405 organic chemistry Process Chemistry and Technology Bioengineering 010402 general chemistry 01 natural sciences Biochemistry Catalysis 0104 chemical sciences Ammonia chemistry.chemical_compound chemistry Organic reaction Urea biology.protein Organic chemistry Organic synthesis Ammonium Malononitrile |
| Zdroj: | Journal of Molecular Catalysis B: Enzymatic. 127:89-92 |
| ISSN: | 1381-1177 |
| Popis: | This is an original work on catalytic performance of urease in organic synthesis which in one-pot dissociation of urea and condensation of the in situ generated ammonia with aldehydes, acetophenones, and malononitrile occurs in water to give 2-amino-3-cyanopyridines. Comparative experiments with ammonium salts supported the enzymatic specify of 0.01 g/mL (50 U/mg) of urease for bio-production of ammonia, while trace amount of heavy metal ions such as Pb 2+ , Hg 2+ , and Ag + inhibit these specific reactions. The scalability and promiscuity of urease facilitate the applicability of the process for biotechnological organic reactions based on ammonia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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