Surprising selectivity in the transformation of dimethoxy azaindoles

Autor:	Dedong Wu, Kirsten D. Gesenberg, Prashant P. Deshpande, Nachimuthu Soundararajan, John Castoro, Feng Xu, Qi Gao, Andrew J. Staab, Annie Pullockaran, Charles Pathirana
Rok vydání:	2007
Předmět:	Transformation (genetics) Hydrolysis Chemistry Reagent Organic Chemistry Drug Discovery Organic chemistry Selectivity Biochemistry Single crystal Demethylation
Zdroj:	Tetrahedron Letters. 48:2675-2677
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2007.02.076
Popis:	Transformation of 4,7-dimethoxy-6-azaindole into 4-hydroxy-7-methoxy-6-azaindole or 7-hydroxy-4-methoxy-6-azaindole can be readily controlled by careful selection of a reagent. Treatment with concentrated HCl results in hydrolysis at the 4-position exclusively, while TMS-I provides demethylation at the 7-position only. Products were unambiguously identified by single crystal X-ray crystallography.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a84d0851c0621ea9620a73501b73dc03 https://doi.org/10.1016/j.tetlet.2007.02.076 Zobrazit plný text záznamu Full Text from ScienceDirect