OP31.08: Intima media thickness and lipid profile at delivery in pregnancies complicated by intrauterine growth restriction

Autor: S. Vedovato, Chiara Cosma, Vincenzo Zanardo, E. V. Cosmi, Ambrogio P. Londero, Annunziata Lapolla, Diego Faggian, M. Bertin, Mario Plebani, M. Camerin, Daniele Trevisanuto, Silvia Visentin
Rok vydání: 2012
Předmět:
Zdroj: Ultrasound in Obstetrics & Gynecology. 40:151-151
ISSN: 0960-7692
DOI: 10.1002/uog.11697
Popis: centile with normal Doppler umbilical artery (UA) and intrauterine growth restriction (IUGR), EFW 2 standard deviation. aIMT was measured by ultrasonography during third trimester. Carbohydrate profile in mothers and fetuses at delivery was assessed. Results: Between 165 women enrolled, 97 were controls, 57 SGA and 11 IUGR. There were no significant differences in maternal age and BMI among the groups. IUGR presented a lower birth weight and a higher aIMT compared to SGA and AGA fetuses (P < 0.05). There was a significant positive correlation between maternal and fetal values for adiponectin, insulin, glucose and HOMA index. Adiponectin was significantly lower in the mother than in the fetus (P < 0.05) while NEFA and glucose were higher (P < 0.05). Maternal adiponectin and NEFA in SGA were significantly higher than in AGA (P < 0.05); moreover there was a significant positive correlation of fetal glucose with fetal aIMT not observed in AGA (P < 0.05), and in SGA fetuses a high aIMT correlated with high insulin resistance. In addition, in IUGR high aIMT was associated with high insulin concentrations. A significant negative correlation between maternal adiponectin and fetal aIMT was found in AGA, while in the SGA group the correlation was significantly positive (P < 0.05). Conclusions: This study suggests that aIMT could be associated with fetal glucose metabolism alteration, and that maternal metabolic disorders might reflect on fetal metabolism and influence the structure of fetal vessels.
Databáze: OpenAIRE
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